Cellular Networks and Molecular Therapeutic Targets

Soddu Silvia
Cellular Networks and Molecular Therapeutic Targets
Tel. 065266 2492
(E-mail)
Curriculum Vitae

RESEARCH PROJECTS

Cellular networks and new therapeutic targets are key areas for innovation in the field of cancer therapy. The potential targeted pathways for personalized cancer therapies consist in oncogenic signals and the events generated by biochemical and/or genetic alterations that characterize cancer cells. The mission of our Unit is to develop and sustain sound expertise in these areas by strategically linking them to understanding the hierarchy of therapeutic targets and the molecular mechanisms underpinning the pharmacological action of innovative as well as repositioned drugs to be employed in cancer therapy. This Unit has a dual function. On one hand, it aids researchers and clinicians to plan preclinical and clinical research activities, as well as to conduct, stimulate and support research programs integrated into innovative investigator-driven clinical trials. On the other hand, it assists other researchers who aim to discover and plan to develop novel biomarkers and therapeutic agents.

Particular attention is dedicated to:
• overcome drug resistance in cancer by hypothesis-driven approaches and computational drug repositioning toward targeted therapies;
• study the mitosis-associated activities of DNA damage response factors (i.e., p53, HIPK2, ATM) and their contribution to chromosomal instability (CIN).