In campo oncologico la ricerca traslazionale verifica la possibilità di trasformare le scoperte scientifiche che arrivano dal laboratorio in applicazioni cliniche per ridurre l’incidenza e la mortalità per cancro. Sono molti gli studi in corso di ricerca traslazionale condotti dalla Unità di Urologia dell’Istituto Regina Elena.
Di seguito un elenco delle recenti pubblicazioni di ambito traslazionale.
- Novel Diagnostic Biomarkers of Prostate Cancer: An Update. Curr. Med. Chem. 2019 https://www.ncbi.nlm.nih.gov/pubmed/30215331
- Organoids as a New Model for Improving Regenerative Medicine and Cancer Personalized Therapy in Renal Diseases. Cell. Death Dis. 2019 https://www.ncbi.nlm.nih.gov/pubmed/30814510
- Predicting biological behaviour of newly diagnosed renal masses: a possible role of cell proliferation biomarkers? Ann Transl Med. 2019 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685880/
- Emerging role of secreted miR-210-3p as potential biomarker for clear cell Renal Cell Carcinoma metastasis. Cancer Biomarkers, 2019 (in stampa)
- Ride the Green Light: Indocyanine Green-marked Off-clamp Robotic Partial Nephrectomy for Totally Endophytic Renal Masses. Eur Urol. 2019 https://www.ncbi.nlm.nih.gov/pubmed/30262342
- Urethra and Ejaculation Preserving Robot-Assisted Simple Prostatectomy: Near-Infrared Fluorescence Imaging-Guided Madigan Technique. Eur Urol 2019 https://www.ncbi.nlm.nih.gov/pubmed/30553615
- Metabolic syndrome increases the risk of upgrading and upstaging in patients with prostate cancer on biopsy: a radical prostatectomy multicenter cohort study. Prostate Cancer Prostatic Dis. 2018 https://www.ncbi.nlm.nih.gov/pubmed/29867154
- The new Epstein Gleason score classification significantly reduces upgrading in prostate cancer patients. Eur J Surg Oncol. 2018 https://www.ncbi.nlm.nih.gov/pubmed/29395435
- Chromogranin A as a biomarker for prostate cancer: is it actually relevant for clinical practice? Future Oncol. 2018 https://www.ncbi.nlm.nih.gov/pubmed/29712494
- Renal cancer: new models and approach for personalizing therapy. J Exp Clin Cancer Res. 2018 https://www.ncbi.nlm.nih.gov/pubmed/30185225
- Secreted miR-210-3p as non-invasive biomarker in clear cell renal cell carcinoma. Oncotarget 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642499/
- C-Met/miR-130b axis as novel mechanism and biomarker for castration resistance state acquisition. Oncogene 2017 https://www.ncbi.nlm.nih.gov/pubmed/28192399
- Keap1/nrf2 pathway in kidney cancer: frequent methylation of keap1 gene promoter in clear renal cell carcinoma. Oncotarget 2017 https://www.ncbi.nlm.nih.gov/pubmed/28061437
- An evaluation of morphological and functional multi-parametric MRI sequences in classifying non-muscle and muscle invasive bladder cancer. Eur Radiol. 2017 https://www.ncbi.nlm.nih.gov/pubmed/28181054
- Metabolic syndrome is associated with advanced prostate cancer in patients treated with radical retropubic prostatectomy: results from a multicentre prospective study. BMC Cancer. 2017 https://www.ncbi.nlm.nih.gov/pubmed/27386844
- Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation. Oncotarget 2016 https://www.ncbi.nlm.nih.gov/pubmed/27144525
- Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation. Oncotarget. 2016 https://www.ncbi.nlm.nih.gov/pubmed/26716650
- A micro RNA code for prostate cancer metastasis. Oncogene. 2016 https://www.ncbi.nlm.nih.gov/pubmed/26073083
- AMBRA1 and SQSTM1 expression pattern in prostate cancer. Apoptosis 2015 https://www.ncbi.nlm.nih.gov/pubmed/26423274
- PCA3 in prostate cancer and tumor aggressiveness detection on 407 high-risk patients: a National Cancer Institute experience. Journal of Experimental & Clinical Cancer Research 2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324853/
- Novel kidney segmentation system to describe tumor location for nephron-sparing surgery. World J Urol. 2015 https://www.ncbi.nlm.nih.gov/pubmed/25159872
- Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy. World J Urol. 2015 https://www.ncbi.nlm.nih.gov/pubmed/25542395
- Significant increase in detection of prostate cancer recurrence following radical prostatectomy with an early imaging acquisition protocol with ¹⁸F-fluorocholine positron emission tomography/computed tomography. World J Urol. 2015 https://www.ncbi.nlm.nih.gov/pubmed/25577130
- Immunomodulatory effects of total intravenous and balanced inhalation anesthesia in patients with bladder cancer undergoing elective radical cystectomy: preliminary results. J Exp Clin Cancer Res. 2013 https://www.ncbi.nlm.nih.gov/pubmed/23374147
- Silencing of GSTP1, a prostate cancer prognostic gene, by the estrogen receptor-β and endothelial nitric oxide synthase complex. Mol Endocrinol. 2011 https://www.ncbi.nlm.nih.gov/pubmed/22052999
- Deregulation of Aurora kinase gene expression in human testicular germ cell tumors. Andrologia. 2010 https://www.ncbi.nlm.nih.gov/pubmed/20629650
- Increased expression of urokinase plasminogen activator and its cognate receptor in human seminomas. BMC Cancer. 2010 https://www.ncbi.nlm.nih.gov/pubmed/20403162
- Incidence of high chromogranin A serum levels in patients with non metastatic prostate adenocarcinoma. J Exp Clin Cancer Res. 2010 https://www.ncbi.nlm.nih.gov/pubmed/21162758
- An open, randomised, multicentre, phase 3 trial comparing the efficacy of two tamoxifen schedules in preventing gynaecomastia induced by bicalutamide monotherapy in prostate cancer patients. Eur Urol. 2010 https://www.ncbi.nlm.nih.gov/pubmed/19481335
- Up-regulation of the inflammatory-reparative phenotype in human prostate carcinoma. Prostate. 2009 https://www.ncbi.nlm.nih.gov/pubmed/19444819
- Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. J Clin Invest. 2009 https://www.ncbi.nlm.nih.gov/pubmed/19363294
- Urinary estrogen metabolites and prostate cancer: a case-control study and meta-analysis. J Exp Clin Cancer Res. 2009 https://www.ncbi.nlm.nih.gov/pubmed/19814782
- Independent prognostic value of tumor diameter and tumor necrosis in upper urinary tract urothelial carcinoma. M. BJU Int. 2009 https://www.ncbi.nlm.nih.gov/pubmed/18990140
- Genetic profile identification in clinically localized prostate carcinoma. Urol Oncol. 2009 https://www.ncbi.nlm.nih.gov/pubmed/18534873
- Expression of Fas and Fas ligand in human testicular germ cell tumors. Int J Androl. 2009 https://www.ncbi.nlm.nih.gov/pubmed/17916181
- Familial papillary renal carcinoma: cytogenetic characterization in normal and tumor tissues in two brothers. A case report. Urol Oncol. 2008 https://www.ncbi.nlm.nih.gov/pubmed/18452823
- Indicators of sexual and somatic development and adolescent body size in relation to prostate cancer risk: results from a case-control study. Urology. 2008 https://www.ncbi.nlm.nih.gov/pubmed/18280559
- Adverse genetic prognostic profiles define a poor outcome for cystectomy in bladder cancer. Exp Mol Pathol. 2007 https://www.ncbi.nlm.nih.gov/pubmed/17950275
- Epithelial-restricted gene profile of primary cultures from human prostate tumors: a molecular approach to predict clinical behavior of prostate cancer. Mol Cancer Res. 2006 https://www.ncbi.nlm.nih.gov/pubmed/16513839
- Cytogenetic profiles as additional markers to pathological features in clinically localized prostate carcinoma. Cancer Lett. 2006 https://www.ncbi.nlm.nih.gov/pubmed/16002207
- Status of the p53, p16, RB1, and HER-2 genes and chromosomes 3, 7, 9, and 17 in advanced bladder cancer: correlation with adjacent mucosa and pathological parameters. J Clin Pathol. 2005. https://www.ncbi.nlm.nih.gov/pubmed/15790699
- Accumulation of genetic changes during the development and progression of bladder cancer. Pathologica. 2005 https://www.ncbi.nlm.nih.gov/pubmed/16440640
- Analysis of HER2 expression in primary urinary bladder carcinoma and corresponding metastases. BJU Int. 2005 https://www.ncbi.nlm.nih.gov/pubmed/16042748
- Analysis of genetic alterations in normal bladder urothelium. Urology. 2004 https://www.ncbi.nlm.nih.gov/pubmed/15302516
- Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimens. Cancer Lett. 2003 https://www.ncbi.nlm.nih.gov/pubmed/12536079
- Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification. J Am Soc Nephrol. 2002 https://www.ncbi.nlm.nih.gov/pubmed/12239244
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